Dyclonine hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

达克罗宁是一种口腔麻醉剂，可在 Sucrets 中找到，这是一种非处方润喉糖。

Dyclonine is an oral anaesthetic found in Sucrets, an over the counter throat lozenge.(In Vitro):Dyclonine hydrochloride (50 μM; 24 h) sensitizes cancer cells to deficiency of cysteine and GSH.Dyclonine hydrochloride (0-2048 μg/mL; 24 or 48 h) shows significant bactericidal and fungicidal activity. (In Vivo):Dyclonine hydrochloride (5 mg/kg; i.p.; single daily for 24 days) sensitizes the involucrin+ differentiated tumor cells to sulfasalazine treatment in vivo.Dyclonine hydrochloride (5 mg/kg; i.p.; single daily for 21 days) suppress the growth of tumors formed by ALDH3A1-expressing gastric cancer stemlike cells when combines with sulfasalazine.

Dyclonine hydrochloride (50 μM; 24 h) sensitizes cancer cells to deficiency of cysteine and GSH.Dyclonine hydrochloride (0-2048 μg/mL; 24 or 48 h) shows significant bactericidal and fungicidal activity. Cell Viability Assay Cell Line:HSC-4 cells Concentration:50 μM Incubation Time:24 hResult:Inhibited ALDH activity and induced 4-HNE accumulation in GSH-depleted cancer cells.Cell Viability Assay Cell Line:S. aureus, B. subtilis, E. coli, T. mentagrophyteConcentration:0-2048 μg/mL Incubation Time:24 h (for bacterial), 48 h (for fungi) Result:Showed good antibacterial and antifungal activity, with minimum microbicidal concentration of 0.006%, 0.025%, 0.012% and 0.025% for S. aureus, B. subtilis, E. coli, T. mentagrophyte, separately.

Dyclonine hydrochloride (5 mg/kg; i.p.; single daily for 24 days) sensitizes the involucrin+ differentiated tumor cells to sulfasalazine treatment in vivo.Dyclonine hydrochloride (5 mg/kg; i.p.; single daily for 21 days) suppress the growth of tumors formed by ALDH3A1-expressing gastric cancer stemlike cells when combines with sulfasalazine. Animal Model:Athymic nude mice (HSC-2 cells implanted model).Dosage:5 mg/kg Administration: Intraperitoneal injection; single daily for 24 days (combine with sulfasalazine).Result:Attenuated the formation of tumors by HSC-2 cells implanted in nude mice when combined with sulfasalazine.Animal Model:C57BL6 mice (K19-Wnt1/C2mE-KP cells implanted model).Dosage:5 mg/kg Administration:Intraperitoneal injection; single daily for 21 days (combine with sulfasalazine).Result:Enhanced the antitumor effect of sulfasalazine on HNSCC tumors consisting of CD44vhigh stemlike tumor cells and involucrin+ differentiated tumor cells.

Dyclonine Hydrochloride | Dyclonine HCL | Dyclone | Dyclothane | Tanaclone | Sucrets | Tanac

Membrane Transporter/Ion Channel

Sodium Channel

Sodium Channel

Neurological Disease

——

536-43-6

325.87

C18H27NO2·HCl

>98% (HPLC)

Ethanol: 36 mg/mL (110.47 mM); Water: 6 mg/mL (18.41 mM); DMSO: 15 mg/mL (46.03 mM)

CCCCOC1=CC=C(C=C1)C(=O)CCN2CCCCC2.Cl

1-(4-butoxyphenyl)-3-piperidin-1-ylpropan-1-one;hydrochloride

(-20℃)

With Ice Pack

≥ 2 years